A Comparative Study on Condition of Wounds of Feracrylum and Haemocoagulase

Singh K.K.¹, Sunita Meshram², Patle D.R.³, U. S. Paikra⁴

¹Associate Professor, Department of Surgery, Government Medical College, Jagdalpur (C.G.)

²Assistant Professor , Department of Surgery, Government Medical College, Jagdalpur (C.G.)

³Professor and HOD, Department of Surgery, Government Medical College, Jagdalpur (C.G.)

⁴Dean, Government Medical College, Jagdalpur (C.G.)

*Corresponding Author E-mail: drkrishna2272@gmail.com

ABSTRACT:

BACKGROUND: Wound Healing represents a highly dynamic integrated series of cellular physiologic and biochemical events, which occur exclusively in whole organisms. Clinically wound healing differ in simple closed wounds and open wounds. "All Real Surgeons Have Been Interested In Wound Repair".- Whipple's Dictum

AIMS and OBJECTIVE: To know the efficiency of Feracrylum and Haemocoagulase in wound healing. Design of study : On hospital based prospective study.

MATERIAL AND METHODS: One hundred cases divided into two groups . Each group consists of 50 patients and one group instilled locally (wound) with one percent feracrylum while the other group haemocoagulase and results were interpretated on discharge.

RESULTS: Majority of wound healed by 14th day. Discharge from wounds were noticed in a few cases in early post operative period. Both Feracrylum and Haemocoagulase promotes post operative wound healing by creating adverse atmosphere for infection.

KEYWORDS: Haemocagulase and Feracrylum.

INTRODUCTION:

"All Real Surgeons Have Been Interested In Wound Repair". –

Whipple's Dictum

The response of tissue to wounding has five major components viz. inflammation, fibroplasias, angiogenesis, connective tissue synthesis and re - epithelialisation. The healing process translates the mechanical injury into cellular and biochemical signals. Orderly repair must include messages for initiation of the host response, modulation of the duration of response and termination of the process once repair is sufficient. The wounding process disrupts capillaries and cause them to thrombose. Bothrothrombin is a protease with a specific action on substrates similar to that of thrombin itself .

However, it differs from thrombin in that it is not inhibited by any of the known thrombin inhibitors. Blombaecketal (1) while thrombin separates only fibrinopeptide A from fibrinogen copelyetal (2). The remaining Des AB fibrinmonomer for thrombin and Des A fibrinmonomer for bothropothrombin produce polymerize form. Feracrylum is a local haemostatic and antiseptic agent. It has also antibacterial activity against many grams negative and positive micro- organism and various pathogenic fungi. By taking into account the above facts and on recommendations that studies must be conducted whenever and wherever chances arise to promote research. Garg Narendrak (3 and 4) the authors have undertaken this study with the objective to known the effectiveness of fercrylum and haemocoagulase in wound healing.

MATERIAL AND METHODS:

The study sample comprised of randomly selected 50 patients each for Haemocoagulase and Feracrylum patients admitted in routine and in emergency was thoroughly enquired for age, sex, occupation, income presenting symptoms. A detailed present, past, family and personal history was obtained from the patient himself/ herself from the attendants if patient was not in position to narrate the history etc. A through clinical and local examination was done to make a surgical diagnosis and associated problem if any ? During clousre of wound one percent feracrylum was instilled locally in one group of 50 cases by subcutaneous (s/c), intermuscular (I/m) and combined (s/c + I/m) level. Similary in another group of 50 patients haemocogulase was administered locally at different level of wound as in case of feracrylum with the help of sterilized disposable syringe. The condition of wound on discharge was taken in consideration to evaluate the efficiency of both the drug.

OBSERVATION AND DISCUSSION:

On analysis of the collected data it was noticed that 95.83% wound were healed on discharge of patient in Haemocoagulase in comparison to 91.66% in Feracrylum cases, through s/c level, while only 4.16% cases show gapping in s/c route in Haemocoagulase again 08.33% in Feracrylum (Table - I). As far as results of intermuscular level of instillation of both drugs were considered in Haemocoagulase all wounds of 100.00 % cases were healed in contrast to 80.00% in Feracrylum wounds. Feracrylum groups of I/m 20.00% cases showed gapping while there was nil percentage in the haemocoagulase group. Table further reveals that there were all 100% wounds of all sampled cases were healed with haemocoagulase in combined I/m + s/c level of instillation in comparison to their counterpart Feracrylum group where 93.75% wound found healed at the time of discharge of patients and the remaining 06.25% can show gaping of wounds. Dunphyetal (5) established that this secondary wound healing phenomenon was related entirely to local factors at the wound site and not associated with the circulating wound hormones.

TABLE – I-Comparison of condition of wounds at the time of discharge of patients.

S.No	Condition of Wound	Haemocoagulase			1 % Feracrylum
S.No	Condition of Wound	S/C n = 24	I/M n = 11	(Combined) S/C + I/M n = 15	S/C n = 24	I/M n = 10	(Combined) S/C + I/M n = 16
1	Discharge	nil	nil	nil	nil	nil	nil
2	Gapping	01 (4.16	nil	nil	2 (08.33)	02 (20.00)	01 (06.25)
3	Healed	23 ( 95.83	11(100.00)	15 (100.00)	22 (91.66)	08 (80.00)	15 (93.75)
	Total	24 (100.00)	11 (100.00)	15 (100.00)	24 (100.00)	10(100.00)	16(100.00)

CONCLUSION AND RECOMMENDATIONS:

From above observations and discussion the authors reached to the conclusion that higher proportion of wound were healed through all three level of instillation of Haemocoagulase in comparison to Feracrylum one percent. As such there is an scarcity of such studies hence authors recommend to get a comprehensive picture of the situation more and more such studies must be undertaken with longer sample size. The results of these studies including the present one will act as foundation for the new search which is the need of the hour.

REFERENCES:

1. Blombaeck B, Blombaeck M and Nilsson J.M coagulation studies on reptilase an extract of a venom from Bothrops Jararca, Thromb, Diath. Haemo 1, 1 1957.

2. Copley A.L and Luchini B.W finding of humanfibrinogen to native and fraction fibrins and inhibition of polymerisation of a new human fibrin monomer by fibrinogen, life sciences 3, 1293 (19640 pregamon press, inc, printed in USA.

3. Garg narendra K and Sharma AB Epidemiological profile of patient attending a tertiary care Hospital, Muktasar, Punjab.

4. Garg Narendra K Evaluation of impact of emesis and emesis plus purgation Research J of Pharmacology and Pharmacodynamics 2 (2) i 201 - 202.

5. Dunphy J.E and Jackson QS practical application of experiment studies in the case of primarily closed wound. Ancer J. Surg (1962) 104 : 273

Received on 28.05.2015 Modified on 12.06.2015

Res. J. Pharmacology & P’dynamics. 7(3): July-Sept., 2015; Page 135-136

DOI: 10.5958/2321-5836.2015.00025.7